Are these okay:
Are you making money off of your properties in Houston?
And
Are you making money with your properties in Houston?
The combination "off of" is horrible and always unnecessary, in my opinion. Just use "off". However, in this particular case "off" is not very good English anyway.
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The combination "off of" is horrible and always unnecessary, in my opinion. Just use "off". However, in this particular case "off" is not very good English anyway. You can say:
Are you making money from your properties in Houston?
"with" is possible too.