Why, when, where, how

An organ transplant is a medical operation in which an organ is taken from one person and placed into the body of another. The problem (of/for/with/from?) organ transplants is that most organs inclusive of hearts, livers, or kidneys come from people killed in road accidents, but in recent years there has been fewer and fewer road accident deaths. New sources for transplants must be found to answer teh need. This is _?_ xenotransplanation comes in.
A) why
B) when
C) where
D) how
Which one is correct?