While I was writing the following sentence, I found it really difficult to decide which expression should I use: "which is", "which are" or "those are". This is mainly attributed to the fact that I wanted to address "mathematical and scientific knowledge", which is plural, though "everyone's cup of tea" is singular.
However, everyone cannot follow computer and engineering courses as it required significant mathematical and scientific knowledge which is / which are / those are not everyone's cup of tea.
The noun in question is "knowledge," which is singular. "Mathematical" and "scientific" modify "knowledge. However, I understand your conundrum.
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The noun in question is "knowledge," which is singular. "Mathematical" and "scientific" modify "knowledge. However, I understand your conundrum. Why not make it two sentences...and you seem to be heading toward that with your suggestion of "those are." Try this:
However, everyone cannot follow computer and