The Google hits are all based on a line from a song by Frank Zappa and the Mothers of Invention (Burnt Weeny Sandwich, 1970):
'I went to the store when they opened up the door I said: "Please please please gimme some more" White Port & Lemon Juice, White Port & Lemon Juice, White Port & Lemon Juice, Ooh what it do to you!
As such I dont have any context, but while conversating with my friend it came to me that using "what it does" seems to be little odd then I searched for "what it do" on google and I got pretty good result which shows we do use it.