1) What's up with you?
2) What is it with you?
3) What's with you?
htrek What's the difference between the three phrases? 3) What's with you? '
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htrek What's the difference between the three phrases? (Original post)Quote 1) What's up with you?2) What is it with you?3) What's with you?
They are casual and synonymous when used to mean 'What is your problem?'