What's the difference between ?

Have you tried looking them up in the dictionary first?

www.onelook.com

Anonymous Come out v.s come up?

There may be multiple meanings of each, but the most common ones that come to mind are these:

come out ~ exit from an enclosure, from the viewpoint of one outside; (for information, e.g., secret information) to be revealed
come up ~ walk to a higher place; (for information) to appear, e.g., as a topic of conversatio