<b><i>___</i> with being so busy both at work and at home, she became increasingly tired and bad-tempered.</b><br/><br/><br/><br/><b>A: How</b><br/><br/><b>B: Where</b><br/><br/><b>C: Which</b><br/><br/><b>D: What</b><br/><br/><br/><br/>This is from a text. The correct answer is What. My question is what is the meaning of “What with” in this sentence? Thanks.