The second sentence is not a natural or grammatical way of asking the usual question about the meaning of the word (as is asked by the first sentence). g. from a list) mean the same as "hydrophobic".
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geoyo Is there a difference between the following sentences:What does hydrophobic mean?Another country heard from.What means hydrophobic?
GPYa less usual sense of asking which other word(s) (e.g. from a list) mean the same as "hydrophobic".Gosh! In that case I'd say Which one (of these) means "hydrophobic"?
CalifJimGosh! In that case I'd say Which one (of these) means "hydrophobic"?I agree that is usual, but nevertheless I maintain that "What means hydrophobic?" is "theoretically possible" as I initially said, along with the other caveats that you chose not to quote.
geoyoSo would it be acceptable to ask "what means life?". The answer could be "it means joy". In that case, I asked what other thing means life. Is that correct?"It means joy" (= "Life means joy") is an answer to "What does life mean?".