It's up to, not upto. The meaning is similar to saying "What are you occupied with now" or "What's keeping you busy these days".
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samadaslamThanks. But what I guessed every time when said to me that what is my level untill now. Is it right too?
Anonymous When ... what you are up to.. ... does it simply mean that he wants to know what are you doing...????No. That is said as "What have you been up to?" It asks what someone has been doing during some time when you have not seen them.