What does my brain is fried means?

Probably it alludes to the negative long-term effect of drug abuse.

AnonymousWhat does "My my brain is fried" means mean?

Too many S's. Use only one per clause.

It is a phased used when you are learning something or doing something that is very thought intensive and you reach a point where your head begins to feel cluttered and it gets hard to think. That is when your brain is fried. The solution is usually to take a nap.

It has nothing to do with drug use, at least the way I've always heard it used.

Or it could be I've been studying so much my brain needs a rest.

it means "I have thought so much that it hurts to think anymore"

It does not necessarily refer to drug abuse.
I think you are confusing the frying egg anti-drug campaign of the Reagan years.
"This is your brain" "This is your brain on drugs."

It means that you're exhausted, really tired.

it means that you have been working too much and your brain literally is done and cannot take any more information.

How rude! They didn't ask for a grammar lesson.

my brian is fried tryin to lean wat my brain is fryed mean