Henryh 1. What happened to these flowers? OR What happened with these flowers?
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Henryh1. What happened to these flowers? OR What happened with these flowers? (I can see they are all dead.)Very generally both mean the same thing. In certain contexts I suppose there could be a slight difference. In your example (the flowers are dead) if you said "with" you could be implying that someone took action to kill them but saying "to"