In response to your questions, I would say: 1. "It was me who wrote the last comment in your profile" This is because the "me" is part of the object of the sentence. 2.
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DrNorman1. "It was me who wrote the last comment in your profile" This is because the "me" is part of the object of the sentence.'Me' is not the object of anything in that sentence. That is why purists would insist on 'I'., though manyt native speakers would say 'me'.