Yes, but not in the sense you intend, from what I can tell.
You can say, "He was the only voice of reason in the debate," or, "The role of reason in Kant's philosophy was..." Are those uses are different from the ones you have in mind?
You can't say, "His reason in baking a cake was to impress his wife." That sounds bad. Better: "His reason for baking a cake was to impress his
Sure. I wanted to say "I see a great reason in", it sounds close to your example: "The role of reason in Kant's philosophy was", but I'm not sure, I just cant find the pattern.