MustAsk What are the most important factors to you in starting your own business? This is fine as is. MustAsk would it sound better with "with regard to" instead of "in"?
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MustAskWhat are the most important factors to you in starting your own business?This is fine as is.
MustAskwould it sound better with "with regard to" instead of "in"?No. I don't think so. That substitution is grammatically correct and perfectly understandable, but I don't think it improves anything.