I wouldn't like to be a pilot because you are responsible for [the] lives of many people on the plane.
the lives of ... Chances are that you'll need 'the' when 'of' follows. It's not 100% true, but it works most of the time.
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the lives of ...
Chances are that you'll need 'the' when 'of' follows. It's not 100% true, but it works most of the time.
CJ