The administration of a medicine is a common but important clinical procedure. It is the manner in which a medicine is administered that will determine to some extent whether or not the patient gains any clinical benefit, and whether they suffer any adverse effect from their medicines.
Please explain the grammatical form and function of 'that' in 'that will determine...'
what does the dummy subject 'it' refer to in 'it is the manner....?
It is the manner in which a medicine is administered [ that ____will determine to some extent whether or not the patient gains any clinical benefit, and whether they suffer any adverse effect from their medicines ]. Your sentence is an example of an it -cleft construction equivalent to The manner in which a medicine is administered will determine … The underlined relative clause straightforwardly modifies "manner", but the bracketed relative clause, as part of the cleft construction, is not quite the same as an integrated (defining) relative, and doesn't have the same modification properties. "That" belongs in the category (part of speech) 'subordinator'.
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It is the manner in which a medicine is administered [that ____will determine to some extent whether or not the patient gains any clinical benefit, and whether they suffer any adverse effect from their medicines].
Your sentence is an example of an it-cleft construction equivalent to The manner in which a medicine is administered will determine …