substance vs chemical

0A police source told The Associated Press the substance was believed to be triacetone triperoxide, or TATP, an explosive used in the 2005 London bombings. 02br
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00One weapons expert said even a tiny amount of TATP could blow a person's hand off. "It is very unstable, very sensitive to both friction and shocks," Svante Karlsson, a weapons expert at the Swedish Defense Research Agency, told AP, adding the 01b00substance02b00 had no civilian use. 02br
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00Can I replace substance with chemical without change of meaning?02br
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00Thanks!0-