Well,here I think you used " and " to mean not only science is hard but ALSO physics,so I wouldn't say "is" but "are" because there are two subjects which are difficult not one.
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EeelearnerHi,when one has a sentence such as the following, do we need the singular or plural form? I am trying to say that science is hard and physics is especially hard.There is only one subject, which is science. "
"The subject of science, and physics in particular, is very hard.
EeelearnerScience, and mathematics as well, is/are hard. This is a very messy sentence.
Just say 'Science and mathematicas are hard.'
It's also messy in that it raises the question of whether it has a singular or plural subject.