You take three populations of mice embryos, one, you inject with embryonic stem cells, the second you inject with stem cells which were made pluripotent through stress, third, you don't do anything to at all.
You let all the populations come to term, be born and then you watch them all for signs of disorder. What you hoping for is that the both the regular stem cells and the stress created stem cells will be utilized by their embryonic hosts just as if they were the embryos' OWN stem cells.
You let all the populations grown into maturity and beyond, let them have kitsand, maybe, let the kitshave kits. (I have no idea how long it takes for a mouse to become an adult, but I know it's not too long.)
The disorders you are looking for could be as evident as failure to thrive or inability to procreate. They could also be as hidden as mutations in the mouse DNA, so you'd have to examine that too.
Meanwhile, the population you left alone is your normal set for comparison.
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My American Heritage Dictionary lists kit as "a young often undersized furbearing animal".
— Philip
My American Heritage Dictionary lists kit as "a young often undersized furbearing animal".
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