I'm sorry, but I cannot make sense of your first sentence. Are there 2 kinds of transgenic mice? One produces Hepatitis B antigen and the other produces Hepatitis B surface antigen?
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Transgenic mice that produces Hepatitis B antigen but lacks viral DNA, called Hepatitis B surface antigen, HBsAG transgenic mouse have also been made. The problem with these mice is that they are tolerating high level of HBsAG that accumulate in the liver and neither acute nor chronic infection is shown.I'm not quite sure about what you want to mean by this, but