?1. She portrayed him as moving with a bible in his hand.
2. She portrayed him like moving with a bible in his hand.
Q1) Are both sentences correct?
(I would say yes)
Q2) Is there any difference in meaning?
fire1 Q1) Are both sentences correct? No. Number 2 is ungrammatical.
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fire1Q1) Are both sentences correct?
No. Number 2 is ungrammatical. Number one is incomprehensible. I think "subject portrayed object as X" requires an adjective or noun for X and not a participle. And how sure are you that you know what "portray" means? Because I don't know what you mean here.
(2) is not correct.
(1) seems unusual or hard to understand. What sense of "portrayed" do you intend? Are you talking about someone drawing/painting a picture?