The comma is properly needed to set off the appositive, as in your #1 and #4 (except that I would put the comma outside the quotation mark-- and 'is starred by' passive is not native; use 'stars John'). )
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Mister MicawberThe comma is properly needed to set off the appositive, as in your #1 and #4 (except that I would put the comma outside the quotation mark-- and 'is starred by' passive is not native; use 'stars John'). When the noun and its appositive are short and very closely associated, the commas are sometimes omitted (My brother Bill is bigger than me.)