Of his?

makski Can you say "work of his" instead of "his work?

Do you mean the work he does as part of his occupation?
Or do you mean something like his artistic output — a painting, a musical composition, a novel?

Give us a sentence as you envision using it.

I'm inclined to answer "no", but you may be asking something different from what I think

What's the difference and when can I use it, if I can use it at all.
I guess I meant the product like a film, not the actual work like directing.

makskiI meant the product like a film

OK. You can't use "work of his" without "a": "a work of his". That means "one of his works/films".
"the work of his" is not used.
"his work" can refer to one of his films that has already been mentioned, but usually it's more specific: "his film".
"his work" and "his works" can both be used

Thank you for explaining it to me. But are you sure about this "a" rule? Where can I look it up?

makskiare you sure about this "a" rule?

In a general way, yes. You will see "work of his" by itself on a rare occasion, but since you don't seem to want to tell me how you're going to use it in a sentence, I shouldn't tell you to go ahead and use it wherever you want.

That's why I'm here, since I can't just google it, it gives me examples with a noun after "his", like "his hands", or "his predecessors".
I'm not sure in which sentence I want to use it, I remember I heard it somewhere, just don't know where, but it got stuck in my head, because of how unusual it sounds. Wish I had a bunch of examples.

makskiit gives me examples with a noun after "his", like "his hands", or "his predecessors".

Hmmm. That's true. That causes a problem.

makskiWish I had a bunch of examples.

Me too. I'm having trouble imagining what kind of example you heard. Unfortunately, I've already said all I know about it. Come back if you see that

CalifJim Come back if you see that sentence again.CJ

I'm sure I'll hear, or read it again somewhere.