Not interested in anything is a major problem in his life.
How can we say it?
kumenglish Not interested in anything is a major problem in his life. This doesn't work. "Not interested in anything" is adjectival, but you are trying to use it as a noun.
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kumenglishNot interested in anything is a major problem in his life.
This doesn't work. "Not interested in anything" is adjectival, but you are trying to use it as a noun. You can say e.g.:
His not being interested in anything is a major problem in his life.
The fact that he is not interested in anything is a major problem in his life.