Should "non-random
attrition of participants" be "non-random
attribution of participants"?
Context:
Intention-to-treat analysis
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intention-to-treat (ITT) analysis of the results of an
http://en.wikipedia.org/wiki/Experiment is based on the initial treatment assignment and not on the treatment eventually received. ITT analysis is intended to avoid various misleading artifacts that can arise in intervention research such as
non-random attrition of participants from the study or
http://en.wikipedia.org/wiki/Crossover_study. ITT is also simpler than other forms of study design and analysis because it does not require observation of
http://en.wikipedia.org/wiki/Compliance_(medicine) status for units assigned to different treatments or incorporation of compliance into the analysis. Although ITT analysis is widely employed in published clinical trials, it can be incorrectly described and there are some issues to its application.
[1] Furthermore, there is no consensus on how to carry out an ITT analysis in the presence of missing outcome data.
[2]More:
http://en.wikipedia.org/wiki/Intention-to-treat_analysis