Motivation Letter please help me

Hi Friends, please help me with writing motivation / personal statement for graduate program. I applied to couple of universities but did get into the none of the universities I applied for. Please help me get into graduate program in US university. I want to apply for spring term. there is one negative thing in my academic journey. I finished BS course in 1991 but graduated in 2009 as there was a course left as I married & moved to another state & GPA is 2.67/4 and joined MS in 2009 and graduated in 2011 with GPA 3.97/4. how to put this break in positive way . Please help friends Thanking you

STATEMENT OF PURPOSE

You see things; and you say “Why?” But I dream things that never were; and I say “Why not?”- George Bernard Shaw

The above philosophy has played an important role in the shaping of my objectives and framing of my plans for the future.
Last few decades have thrown open the doors for unabated technological advancement and has created opportunities of growth in newer dimensions which we never thought existed even a short time ago. To excel in the futuristic workplace of tomorrow, one will need to posses a perfect blend of theoretical study and practical experience. I want to be a part of this exciting race to create a more scientifically advanced tomorrow and I envision Cancer Pathology and Prevention graduate program as a path towards my advancement in this direction. To realize my dreams and to achieve my career goals, I foresee your university as the right destination.
I have always had an interest in science based subjects; especially those related to biology and wanted to do a remarkable work in the field of Applied Life Science. However, I could not accomplish because of family issues. In the meantime, I was married to a scientist and had to move out of my native state to be with him discontinuing education. Later our family extended with a son and a daughter and they became my first priority over my continuing education. Now, as they are grown up and don’t need my constant attention any more, I want to realize my dream to be researcher in the field of Biomedical Sciences and develop new diagnostic and therapeutic technique for prognosis and better outcomes of many complex diseases.
Being a wife of renowned researcher and living in the research community has motivated me to make a unique identity of my own in the field of Biomedical Science. My family responsibilities and priority for my kids held me back for a period from my aspiration to be researcher. As a house wife, I never sat around instead I used to update my knowledge with current research and trends in the field of biology. This helped me to keep in touch with the subject. At the same time getting an Advanced Diploma in Computer Applications aided me a lot in using computer and internet which led me to world of knowledge.
As a first step towards achieving my goal to have a career in the Biomedical Sciences, I joined masters program in the Department of Applied Zoology, XXX University. It is where my knowledge got widens with practical experiences and theoretical study.
During my post graduation the two areas that evoked an ardent interest were ‘Cellular and Molecular Biology’ and ‘Genetics’. The best grades I obtained in my class in these subjects are testimony to and reflection of my zest and zeal for these subjects. My insatiable thirst for delving deep into these subjects made me to take ‘Applied Genetics’ and ‘Genetic Engineering’ as elective subjects in the Department of Biotechnology in second and third semester respectively. Biochemistry and Biostatistics, and Proteomics and Genomics were taken as soft core subjects in second and third semester in the Department of Applied Zoology.
My passion towards theses subjects further motivated me to do a project titled ‘Effects of Mitochondrial DNA Variations on the Occurrence of Diabetes Mellitus in selected South XXX population. Although, there is a strong association between mitochondrial dysfunction and DM, a causal pathogenic relationship remains uncertain. With the given fact that mitochondrial DNA mutations appear to be varying with different populations and regions, identifying such mutations would stimulate research towards estimating its contribution in the etiology of a disease. My study found rRNA, tRNA, and ND1gene mutations in DM patients aiding in the evaluation of mitochondrial DNA variations in the pathogenesis of the diabetes mellitus in southern XXX population.
Seeing my determination and passion, my supervisor let me do a project of my interest despite of no such facilities to conduct this kind of project in our university. Here, I would like to pay my deep respect and gratitude to my mentors Prof. XXX, my under graduate teacher, now a Research Professor in XXX Institute, NY and Dr.YYY, Technical Director, Molecular Diagnostics Laboratory, University of XX Medical Center, XX for their invaluable guidance and moral support through my masters project. Before starting the project I wanted to have hands on experience on basic molecular techniques which were the basic needs to the project. That’s when I approached Dr.YYY in this regard. He readily agreed to accommodate in his lab for a month. This gave me not only exposure to world class laboratory and hands on experience but a chance to interact with experts and learn things by experience. Doing the project independently has helped me acquire a blend of diverse scientific knowledge, analytical skills and time management. Furthermore, in order to be knowledgeable in the breadth of biology, I have attended workshop and symposiums in different streams of biology.
Mitochondrial biology is one of the fastest growing areas in genetics and medicine, connecting scientific disciplines ranging from embryology to cancer, to infectious disease. Because of heterogeneous nature of mitochondrial diseases in clinical presentation and genotype, it’s been a challenge for researchers to evaluate the contribution of specific mitochondrial gene variation in the pathogenesis of the mitochondrial diseases. Given the opportunity, I want to explore the interaction of nucleus and mitochondrial DNA and the role of mitochondria in apoptosis.
Outside my studies, I have always loved to be a part of a work which would do service to society and under privileged people. In US, I have worked in XXX Public Library as a volunteer and have involved in many community services and volunteered many kinds of festivals held in XXX. Here, in XX raised funds for needy students for their education. Other than these, I often indulge myself listening to music, playing badminton and doing yoga.
My search for the best match of objectives, passions and dreams has ended at your university with the best of fundamental research in all avenues of biology. It is my belief that the superior research facilities, the nurturing academic environment, strong faculty and a quality education will fulfil my aspiration to become a researcher with important achievements in the future in my chosen field. I am confident of realizing my goals here, as the best outlook and facilities are available to students with the best of opportunities. I am sure, I am behooved to the University’s requirements with the right goals and attitude towards educational and research excellence. My goal is to train myself thoroughly through my PhD in Biological Sciences.
In conclusion, I must say that I would regard my being admitted to Your University not only as a great honour and success but more as high responsibility and privilege. I will work hard to uphold and further the reputation of such a fine University. As to whether I shall have this honour is your decision but if I do, I will spare no pains to justify it.
I thank you for your time and consideration.

Yours Sincerely,
XXX