" She thinks she's going to move to Hollywood and be a big star. It's a crazy plan, but who's to say she won't succeed? Think of the "what" as a thing whereas the "who" is a person.
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MrPernickety1. What's to say the blood didn't get there during one of those altercationsNote that these examples are followed by a negative statement, which is the typical use I think. What's to say can be used a challenge to prove the opposing case, like How do you know that .... If you reverse the polarity of the statement that follow