No. "look after it" is a correct phrase (meaning "take care of it"), and this could in some situation be followed by another phrase starting with "up", but "look after it up" does not make sense by itself.
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No. "look after it" is a correct phrase (meaning "take care of it"), and this could in some situation be followed by another phrase starting with "up", but "look after it up" does not make sense by itself.