Knowing as she does that I dislike him, she will suspect me, and think that I want to ruin her match. I simply don't know what to make of such a thing. I ... --------
Not quite sure what you are asking here but options 2 and 3 are not grammatically correct.
4) yes this 'knowing as she does' phrasing is well accepted in formal writing. (well, with only one 'a' following it).
Another problem here though is that 'knowing as she does' is very formal, but 'a lot about it' is quite informal, so they create an awkward sentence when combined.