Mr. Tom It's not at all a problem with/for me as regards how many times you have discussed this issue with me. It's not at all a problem with/for me that how many times you have discussed this issue with me.
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Mr. TomIt's not at all a problem with/for me as regards how many times you have discussed this issue with me.If you like this sentence order,
It's not at all a problem with/for me that how many times you have discussed this issue with me.