" "That" works fine, so I guess it must be a determiner, by default. Again relying on my ear, there's a difference in meaning without the comma. " That is, we already know which lesson we're talking about, and the following clause simply confirms it.
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exodejavuIs the "that" a determiner or relative pronoun?A determiner goes with the following noun.
CalifJim Does that introduce a whole clause? Yes. The clause is Reactions can happen slower at lower temperatures.
that is a complementizer. (Some people call it a conjunction.) It links a whole clause in