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CalifJim"during" is possible, but less common.I took a trip to Japan ___ winter vacation. (A) at (B) on (C) during (D) about
My previous comment was meant to refer to the choice between "in" and "on" -- it's always "on" when you have the choice between "in" and "on" and the object of the preposition is "vacation".
You can 'go on vacation' but you cannot '*take a trip on vacation'.