(1) During the difficult times in (his) life, he received a lot of help from his friends.
(2) They fought hard against the challenges in (their) life.
My non-native English speaking friends and I think it's wrong to use the possessive pronouns.
Do you need them? Thanks a lot.
(1) During the difficult times in (his) life, he received a lot of help from his friends. (2a) They fought hard against the challenges in life . (2b) They fought hard against the challenges in their lives .
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(1) During the difficult times in (his) life, he received a lot of help from his friends.
(2a) They fought hard against the challenges in life.
(2b) They fought hard against the challenges in their lives.
"his" is optional in (1), though I think I would include it.
I'm not sure that one really fights against a challenge.