Yes. It depends on how the previous sentence or question was worded.
"I think I'm due for a holiday. If so, I would like to take next Thursday off." For this statement, "I think I'm due for a holiday", and the question "Am I due for a holiday?", the two possibilites are that "it is so" (I am due for a holiday) and "it is not so" (I am not due for a holiday). You c