Sometimes. Or she might just be irritated at something else. Or maybe he's in drag.
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Mister MicawberNo, we don't. It's 'Dear Sir or Madam'.
JandrosUSATwo of our very firmly entrenched customs: Dear Sir or Madam: (salutation for a letter) Ladies and Gentleman, may I have your attention please? Don't ask why, that's just the way it is