That is a mistake. You can't use "as to" that way. The sentence becomes correct when you simply remove "as to". You could make it, "I understood the biological concept that Billy explained last night, but as to how he plans to apply it, I still need some clarification." That isn't especially good, but it is idiomatic and grammatical.
As to means with respect to or about. Here's an example of its correct use: I am confused as to what to do next. The following constructions are redundant and incorrect: Reason why Reason as to why Reason is because Reason why is because Instead, use just reason or reason that.