Both are commonly used as a greeting, as a general inquiry about the other person's health or state of affairs, but #2 is also often used to inquire about the state of a particular project, effort, etc.
Please do not use abbreviations such as "how r u" in this forum. Also, "wanna" is heard in conversation but you should never use it in writing (if you want to be taken seriously).
(From your photo, you look like a man who wants to be taken seriously!)