"Off to L ondon" is probably an abbreviated form of "I'm/We're off to London", meaning that we are departing, or about to depart, on a journey to London. "off from London" doesn't make obvious sense, at least not in isolation. If it is a fragment of a larger sentence then please post the whole sentence.
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"Off to London" is probably an abbreviated form of "I'm/We're off to London", meaning that we are departing, or about to depart, on a journey to London.
"off from London" doesn't make obvious sense, at least not in isolation. If it is a fragment of a larger sentence then please post the whole sentence.