Strictly speaking, the comma is necessary, though many writers lazily leave it out with short introductory phrases.
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SnarfDo you put commas around "therefore" when it's mid-sentence? For example:You certainly could, but I personally, and idiosyncratically, wouldn’t in this particular sentence. Inconsistently, I would use commas around however.
He, therefore, did not know what he was doing.
SnarfShe had nothing but good intentions, a