Dr. George A. Perera had also written about how corticosteroids may be the underlying cause of hypertension. He showed that adrenocorticotropin hormone (ACTH), the hormone that precedes the release of cortisol and aldosterone from the adrenal gland, could increase blood pressure. But it wasn’t until half a century later that fructose in the brain was found to stimulate ACTH release, and thereby increase the secretion of cortisol. Importantly, it was thought that fructose levels would be too low in the body for this to matter to the brain. We’ve since discovered, however, that fructose can be formed in the brain from glucose, particularly in states of insulin resistance.
--- I'm not sure what the part "for this to matter" refers to? Is it clear for you?
Newguest But it wasn’t until half a century later that fructose in the brain was found to stimulate ACTH release , and thereby increase the secretion of cortisol. Importantly, it was thought that fructose levels would be too low in the body for this to matter to the brain. However, it was thought that fructose levels in the body would be too low to make this an important consideration regarding the brain.
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NewguestBut it wasn’t until half a century later that fructose in the brain was found to stimulate ACTH release, and thereby increase the secretion of cortisol. Importantly, it was thought that fructose levels would be too low in the body f