#1 is asking about what used to happen in the past. #2 is asking about what happens generally, at any time. ".
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lucas21c1. Didn't you ever get tired?Did you not, at some/any point in the past, experience/feel tiredness?
lucas21c2. Don't you ever get tired?Do you not, at one point or another (these days/now/in the present), experience/feel tiredness?