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NL888 Posted 13 years ago
Grammar
Does "prospective labeling" mean "potential labeling"?
Context:
Hearing loss due to damage to auditory hair cells is normally irreversible because mammalian hair cells do not regenerate. Here, we show that new hair cells can be induced and can cause partial recovery of hearing in ears damaged by noise trauma, when Notch signaling is inhibited by a -secretase inhibitor selected for potency in stimulating hair cell differentiation from inner ear stem cells in vitro. Hair cell generation resulted from an increase in the level of bHLH transcription factor Atoh1 in response to inhibition of Notch signaling. In vivo prospective labeling of Sox2-expressing cells with a Cre-lox system unambiguously demonstrated that hair cell generation resulted from transdifferentiation of supporting cells. Manipulating cell fate of cochlear sensory cells in vivo by pharmacological inhibition of Notch signaling is thus a potential therapeutic approach to the treatment of deafness.
More:
http://www.cell.com/neuron/retrieve/pii/S0896627312009531
Hearing loss due to damage to auditory hair cells is normally irreversible because mammalian hair cells do not regenerate. Here, we show that new hair cells can be induced and can cause partial recovery of hearing in ears damaged by noise trauma, when Notch signaling is inhibited by a -secretase inhibitor selected for potency in stimulating hair cell differentiation from inner ear stem cells in vitro. Hair cell generation resulted from an increase in the level of bHLH transcription factor Atoh1 in response to inhibition of Notch signaling. In vivo prospective labeling of Sox2-expressing cells with a Cre-lox system unambiguously demonstrated that hair cell generation resulted from transdifferentiation of supporting cells. Manipulating cell fate of cochlear sensory cells in vivo by pharmacological inhibition of Notch signaling is thus a potential therapeutic approach to the treatment of deafness.
More:
http://www.cell.com/neuron/retrieve/pii/S0896627312009531
Top answer
Here is an explanation of prospective labelling in a sociological context. Does it help to understand the concept in a medical context? com/Q/Primary_and_secondary_deviance
- Here is an explanation of prospective labelling in a sociological context.
- Does it help to understand the concept in a medical context?
- com/Q/Primary_and_secondary_deviance
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2 Answers
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Here is an explanation of prospective labelling in a sociological context. Does it help to understand the concept in a medical context?
http://wiki.answers.com/Q/Primary_and_secondary_deviance
http://wiki.answers.com/Q/Primary_and_secondary_deviance
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You will have to research this by Googling "prospective labeling", because it is not an everyday term that everyone knows, but rather a very specialized term in the biological sciences. It appears to me that the terms "prospective labeling" and "retrospective labeling" are used both in sociology and in biology, so you'll have to ignore the articles on sociology.
CJ
CJ
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