It differs by context. A few uses: Give up = relinquish (He gave up the keys to his car when he reached 90 years of age.) Give up = quit a physical struggle (He gave up in his arm-wrestling match because he was too tired to go on.) Give up = not be able to answer ("How many beans are then in this jar?" "I give up; how many?") Give up = desist (She stopped smoking with the