Conjections

In the following exercise, can I use therefore and as a result interchangeably? And however and on the other hand? If not, why can I use them interchangeably? It's really confusing to me.

The advantages and disadvantages of living in the country.

Living in the country is often the secret dream of certain city-dwellers . First of all/first…………(1), in reality it has both its advantages and disadvantages. There are many advantages to living in the country.However( or on ther other hand)(2), you are much closer to nature and can enjoy more peace and quiet. …In addition/moreover………(3), life in the country is much slower and people tend to be more open and friendly. A further advantage is that there is much less traffic, and as a result, it is much safer place to bring up young children.
on the other hand (or however)(4), there are certain drawbacks to life outside the city. …Firstly/first of all…………….(5), because there are fewer people, one has a smaller number of friends. Moreover/in addition.( 6) entertainment, particularly in the evening, is difficult to find. Furthermore, the fact that there are fewer shops and services often means that there are fewer employment opportunities. As a result( or therefore) (7), one may have to travel long distances to work elsewhere, and this can be extremely expensive.

To sum up8), it can be seen that the country is more suitable for some than others. On the whole(9), it is often the best place for those who are retired or who have young children, As a result(or therefore)(10), young, single people who are following a career and who want some excitement are better provided for by life in the city.