What’s the difference: Nope. You’re very helpful.
And
Nope, you’re very helpful.
Are both okay?
It would be helpful to see more context, especially the preceding statement/question, though I can't think of a context in which there would be a material difference between the two.
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It would be helpful to see more context, especially the preceding statement/question, though I can't think of a context in which there would be a material difference between the two.