She can't have gone too far.
vs.
She mustn't have gone too far.
Do they both mean the same?
They are not the same in meaning. The first sentence is okay. The second sentence is ungrammatical.
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They are not the same in meaning. The first sentence is okay. The second sentence is ungrammatical. Note that these sentences are unusual in their structure. The second sentence is okay in the positive: "She must have gone too far.", but ungrammatical in the negative: "She mustn't have gone too far." is ungrammatical. While the first sentence is okay in the negative, "She can't have gone
anonymousDo they both mean the same?
Yes, but "mustn't have gone" is hardly used at all in comparison. It's been that way since about 1850.
(Still, I like "mustn't have", and I use it from time to time.