C is the choice, but I would say, "neither of Amy's two brothers is playing the piano". The original sentence doesn't tell us how many brothers she has, by the way.
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| PRONOUN: | The one and the other: Both were candidates. We are both candidates. Both of us are candidates. |
BMOThanks, but I thought "Both of Amy's brothers" tells us she has exactly two brothers.You are absolutely correct! My oversight.