I would use the comma.
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navitasanOne could argue that (2) means he was as curious as all children are, but I don't think that works here.No, it doesn't work.
navitasanHe was strong as an ox.The analog here is
navitasanDoes the comma make any difference here?It does. It represent, in a written form, a little vocal pause made when the sentence is spoken.
navitasan1 He was curious, as all children are. 2 He was curious as all children are.Does the comma make any difference here?If you want a sentence where a comma makes a difference, here's a good candidate.