herezcheez What are the differences? " isn't. If you remove the question mark from the latter and put a period / full stop ( .
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herezcheezWhat are the differences?"Are you stupid?" is correct grammatically, while "You are stupid?" isn't. If you remove the question mark from the latter and put a period / full stop (.) or even an exclamatory mark (!) instead , then it, too, would be a grammatically correct (assertive or exclamatory) sentence as your first one is.