I prefer "something", but "everyone ... you" is mismatched. You can say: Probably everyone has made someone angry by saying something they shouldn't have.
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teacherJapanOh, that's right Thank you very much for pointing that out:) Does "what" imply that the speaker had a particular phrase in mind , such as "You are an ***.?"That interpretation doesn't fit well with the generality of "Probably everyone ...", which is probably at least part of the reason why "what" does not seem quite such a good fit.